反应详情

温度

60 °C

Anhydrous cupric chloride (8 mg) is added to a mixture of 4-methoxybenzyl alcohol (2.76 g) and 1,3-diisopropylcarbodiimide (3.13 mL) under a nitrogen atmosphere. The reaction is quite exothermic and it is cooled with an ice bath for 1 h. The mixture is then heated for 3.5 h at 60° C. The product was purified by distillation to give O-p-methoxybenzyl-N,N'-diisopropylisourea (4 g).

1. temperatureit is cooled with an ice bath for 1 h
2. distillationThe product was purified by distillation