Chloride → 2-(2'-Bromo-4-fluorophenoxy)tetrahydro-2H-pyran

HRID 2348265Notes

Reaction equation

HRID 2348265 reaction equation
[Br:24][c:25]1[c:26]([OH:32])[cH:27][cH:28][c:29]([F:31])[cH:30]1.[C:33](=[O:34])([O-:35])[O-:36].[Cl-:40].[Cl:41][CH2:42][Cl:43].[K+:37].[K+:38].[Na+:39].[O:1]1[CH2:2][CH2:3][CH2:4][CH:5]=[CH:6]1.[OH2:44].[c:7]1([CH3:8])[cH:9][cH:10][c:11]([S:12]([O-:13])(=[O:14])=[O:15])[cH:16][cH:17]1.[nH+:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>>[O:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]1[O:32][c:26]1[c:25]([Br:24])[cH:30][c:29]([F:31])[cH:28][cH:27]1

Participants

11

Reactant 10

HCID 312ChlorideHCID 813Potassium Cation2×HCID 923Sodium ionHCID 962WaterHCID 6344DichloromethaneHCID 80803,4-dihydro-2H-pyranHCID 19660Carbonate IonHCID 85570p-ToluenesulfonateHCID 6054722-Bromo-4-fluorophenolHCID 4989215Pyridinium

Product 1

HCID 593402472-(2'-Bromo-4-fluorophenoxy)tetrahydro-2H-pyran

Sources & evidence

ORD record
ord-6355b2cc3b454454a0fddf12b3fe1b36
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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