反应详情

温度

80 °C

To a solution of NaOEt (from 3.63 gms Na) in ethanol (500 ml) was added 2,3-dichlorophenylacetonitrile (Example 14.3) in ethanol (150 ml). Ethyl formate (16.67 gms) was then added and the mixture stirred at 80° C. for 45 minutes, before adding a further quantity of ethyl formate (2.78 gms). After stirring at 80° C. for a further 1.5 hours, the precipitate was filtered off and dried in vacuo. The solid was dissolved in water, filtered, acidified with concentrated hydrochloric acid and the precipitate filtered off and dried in vacuo, 14.35 gms, 45% yield.

1. stirringAfter stirring at 80° C. for a further 1.5 hours
2. filtrationthe precipitate was filtered off
3. customdried in vacuo
4. dissolutionThe solid was dissolved in water
5. filtrationfiltered
6. filtrationthe precipitate filtered off
7. customdried in vacuo, 14.35 gms, 45% yield