Ethanol → Diethyl 2-(2,4-dichlorophenyl)malonate

HRID 234930Notes

Reaction equation

HRID 234930 reaction equation
[Na].C(O)C.[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].[C:19](=O)([O:23]CC)[O:20][CH2:21][CH3:22]>>[CH3:18][CH2:17][O:16][C:14]([CH:13]([C:19]([O:20][CH2:21][CH3:22])=[O:23])[C:7]1[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:6]=1[Cl:5])=[O:15]

Participants

5

Reactant 4

HCID 702Ethanol2×HCID 7766Diethyl CarbonateHCID 234291Ethyl (2,4-dichlorophenyl)acetateHCID 5360545Sodium2×

Product 1

HCID 2736112Diethyl 2-(2,4-dichlorophenyl)malonateYield 85%

Procedure

Sodium(1.86 g, 0.081M) was added in portions to absolute ethanol (150 ml) with stirring. After all the sodium had dissolved a solution of ethyl 2,4-dichlorophenylacetate (20 g) in diethyl carbonate (50 ml) was added dropwise. The reaction mixture was heated until EtOH distilled over. The rate of addition was controlled such that it equalled the rate of distillation. After the completion of addition the reaction mixture was heated and distilled for further 4 hours. The cooled reaction mixture was partitioned between water (300 ml) and EtOAc (300 ml) and the organic layer dried and evaporated in vacuo to give a yellow oil (21 g, 85%).

Workup

  1. additionwas added dropwise
  2. distillationdistilled over
  3. additionThe rate of addition
  4. distillationthe rate of distillation
  5. additionAfter the completion of addition the reaction mixture
  6. temperaturewas heated
  7. distillationdistilled for further 4 hours
  8. customThe cooled reaction mixture
  9. customwas partitioned between water (300 ml) and EtOAc (300 ml)
  10. customthe organic layer dried
  11. customevaporated in vacuo

Sources & evidence

ORD record
ord-d16496a5d469407c82d8b36bfd69f46f
Source dataset
uspto-grants-1997_01
Patent number
US05597827

Reaction notes

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