Benzyl Alcohol → HCID 86750241, compound

HRID 234982Notes

Reaction equation

HRID 234982 reaction equation
Cl.[C:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([N:19]3[CH2:24][CH2:23][CH:22]([CH:25]=[C:26]=[O:27])[CH2:21][CH2:20]3)=[O:18])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=[NH:4])[NH2:3].C1(C)C=CC([S:34]([OH:37])(=[O:36])=[O:35])=CC=1.[CH2:39]([OH:46])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1>>[C:5]1([CH3:2])[C:10]([S:34]([OH:37])(=[O:36])=[O:35])=[CH:9][CH:8]=[CH:7][CH:6]=1.[C:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([N:19]3[CH2:24][CH2:23][CH:22]([CH2:25][C:26]([O:46][CH2:39][C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=4)=[O:27])[CH2:21][CH2:20]3)=[O:18])=[CH:13][CH:12]=2)=[CH:9][CH:10]=1)(=[NH:3])[NH2:4]

Participants

4

Reactant 3

HCID 244Benzyl AlcoholHCID 6101p-Toluenesulfonic acidHCID 86750242HCID 86750242, compound

Product 1

HCID 86750241HCID 86750241, compound

Conditions

Temperature
70 °C

Procedure

A mixture of 1.6 g of 4-amidino-4'-[(4-carbonylmethylpiperidino)carbonyl]biphenyl hydrochloride, 50 ml of benzyl alcohol and 1 g of p-toluenesulphonic acid is heated to 70° C. with stirring for 4 hours under 100 mbar and then evaporated down in a water jet vacuum at 140°-150° C. The residue was triturated with ether, the solid product obtained was filtered off and dissolved in dimethylformamide, the solution was evaporated down and the residue was triturated with ether.

Workup

  1. customevaporated down in a water jet vacuum at 140°-150° C
  2. customThe residue was triturated with ether
  3. customthe solid product obtained
  4. filtrationwas filtered off
  5. dissolutiondissolved in dimethylformamide
  6. customthe solution was evaporated down
  7. customthe residue was triturated with ether

Sources & evidence

ORD record
ord-996bfdd8e8fb411e923eb0c80c8f2fd5
Source dataset
uspto-grants-1997_01
Patent number
US05597825

Reaction notes

Loading…