Bromide ion → 2-Chloro-6-(4-fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidine

HRID 2350020Notes

Reaction equation

HRID 2350020 reaction equation
[Br-:1].[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[CH:2]([CH3:3])([CH3:4])[Mg+:5].[Cl:6][c:7]1[n:8][c:9]([Cl:24])[c:10]2[c:11]([n:12]1)[cH:13][cH:14][c:15](-[c:17]1[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]1)[n:16]2.[Cu:30][I:31]>>[CH:2]([CH3:3])([CH3:4])[c:9]1[n:8][c:7]([Cl:6])[n:12][c:11]2[c:10]1[n:16][c:15](-[c:17]1[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]1)[cH:14][cH:13]2

Participants

6

Reactant 5

HCID 259Bromide ionHCID 8028TetrahydrofuranHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 596478432,4-Dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidineHCID 178461726HCID 178461726, compound

Product 1

HCID 579067492-Chloro-6-(4-fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-045819779f8e483b9310a96f7c6368c9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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