Water → HCID 178484691, compound

HRID 2351074Notes

Reaction equation

HRID 2351074 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1.C(N(CC)CC)C.[CH3:14][N:15]([CH3:19])[C:16](Cl)=[O:17].O>C(#N)C>[CH3:14][N:15]([CH3:19])[C:16](=[O:17])[NH:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6598Dimethylcarbamoyl ChlorideHCID 8471TriethylamineHCID 178509299HCID 178509299, compound

Product 1

HCID 178484691HCID 178484691, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Anhydrous 5-aminotetrazole (8.5 g, 0.1 mole) was slurried in 150 ml of acetonitrile. On the addition of triethylamine (10 g, 0.1 mole), the solids dissolved. Dimethylcarbamoyl chloride (13 g, 0.12 mole) was added at once with no exotherm. The mixture was refluxed two hours with the formation of white solids. After cooling, the material was added to cold water to remove by-product triethylamine hydrochloride. The water insoluble material was collected.

Workup

  1. dissolutionthe solids dissolved
  2. temperatureThe mixture was refluxed two hours with the formation of white solids
  3. temperatureAfter cooling
  4. customto remove by-product triethylamine hydrochloride
  5. customThe water insoluble material was collected

Sources & evidence

ORD record
ord-a16f2bf718dc45518fbad1a18d59d701
Source dataset
uspto-grants-1989_10
Patent number
US04871861

Reaction notes

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