Hydrochloric Acid → 3-Aminotetrahydro-2(1H)-pyrimidinone, monohydrochloride

HRID 2351083Notes

Reaction equation

HRID 2351083 reaction equation
C1(C=[N:8][N:9]2[CH2:14][CH2:13][CH2:12][NH:11][C:10]2=[O:15])C=CC=CC=1.[ClH:16]>O>[ClH:16].[NH2:8][N:9]1[CH2:14][CH2:13][CH2:12][NH:11][C:10]1=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54495459tetrahydro-3-[(phenylmethylene)amino]-2(1H)-pyrimidinone

Product 1

HCID 1317161453-Aminotetrahydro-2(1H)-pyrimidinone, monohydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 5.7 g (28.0 mmol) tetrahydro-3-[(phenylmethylene)amino]-2(1H)-pyrimidinone in a mixture of 43 ml water and 43 ml concentrated hydrochloric acid was steam distilled until no additional benzaldehyde condensed. The residual solution was evaporated to dryness, triturated with ethanol and dried in vacuo. Yield 3.07 g, melting point 210°-215° C.

Workup

  1. distillationdistilled until no additional benzaldehyde condensed
  2. customThe residual solution was evaporated to dryness
  3. customtriturated with ethanol
  4. customdried in vacuo

Sources & evidence

ORD record
ord-caccab3206fb436cb5c4f7d5a2a67b1d
Source dataset
uspto-grants-1989_10
Patent number
US04871841

Reaction notes

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