Tetrahydrofuran → HCID 53652916, compound

HRID 2351281Notes

Reaction equation

HRID 2351281 reaction equation
[CH2:1]([O:3][C:4]1[O:9][C:8](=[O:10])[C:7]2[C:11]([CH:15]=[CH:16][CH3:17])=[CH:12][CH:13]=[CH:14][C:6]=2[N:5]=1)[CH3:2].C1C[O:21]CC1>[OH-].[Na+]>[CH2:1]([O:3][C:4]([NH:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]=[CH:16][CH3:17])[C:7]=1[C:8]([OH:21])=[O:10])=[O:9])[CH3:2]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 54550150HCID 54550150, compound

Product 1

HCID 53652916HCID 53652916, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Alternatively, the title compound was prepared by stirring a solution of 2-ethoxy-5-propenyl-4H-3,1-benzoxazin-4-one in THF (5 ml) and 2% sodium hydroxide (5 ml) for 6 hours. The organic solvent was removed by evaporation. The aqueous solution was acidified to pH=2 with dropwise addition of 6 M HCl. The solution was extracted with ethyl acetate and the organic was dried (magnesium sulphate) and evaporated to give an oil.

Workup

  1. customThe organic solvent was removed by evaporation
  2. additionThe aqueous solution was acidified to pH=2 with dropwise addition of 6 M HCl
  3. extractionThe solution was extracted with ethyl acetate
  4. dry with materialthe organic was dried (magnesium sulphate)
  5. customevaporated
  6. customto give an oil

Sources & evidence

ORD record
ord-a4abfb969a4640649de6dec6d4db6fd5
Source dataset
uspto-grants-1989_10
Patent number
US04873232

Reaction notes

Loading…