Diisopropyl Ether → HCID 14210074, compound

HRID 2351389Notes

Reaction equation

HRID 2351389 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]1=2)=[O:3].[CH2:20]([N:22]([CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][N:27]1[CH2:32][CH2:33][NH2:34])[CH2:23][CH3:24])[CH3:21].C(OC(C)C)(C)C>>[CH2:20]([N:22]([CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][N:27]1[CH2:32][CH2:33][NH:34][C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]1=2)=[O:3])[CH2:23][CH3:24])[CH3:21]

Participants

4

Reactant 3

HCID 7914Diisopropyl EtherHCID 132767455-chlorocarbonyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-oneHCID 142100002-[2-[(Diethylamino)methyl]piperidin-1-yl]ethanamine

Product 1

HCID 14210074HCID 14210074, compoundYield 74%

Procedure

Prepared analogously to Example 2 from 5-(chlorocarbonyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 2-[2-[(diethylamino)methyl]-piperidin-1-yl]-ethanamine in a yield of 74% of theory. Colourless crystals, m.p. 123°-125° C. (diisopropylether).

Sources & evidence

ORD record
ord-9853fa857bbe4c71b89f07e6905732d7
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

Loading…