4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one → HCID 54560141, compound

HRID 2351436Notes

Reaction equation

HRID 2351436 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7](=[O:15])[C:6]2=[CH:16][S:17][C:18]([CH3:19])=[C:5]12)=[O:3].[CH3:20][N:21]([CH3:34])[CH2:22][CH2:23][CH2:24][CH:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][NH2:33])[CH2:27][CH2:26]1>C(OC)(C)(C)C>[CH3:34][N:21]([CH3:20])[CH2:22][CH2:23][CH2:24][CH:25]1[CH2:26][CH2:27][N:28]([CH2:31][CH2:32][NH:33][C:2]([N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[NH:8][C:7](=[O:15])[C:6]3=[CH:16][S:17][C:18]([CH3:19])=[C:5]23)=[O:3])[CH2:29][CH2:30]1

Participants

4

Reactant 2

HCID 142099804-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-oneHCID 19845999HCID 19845999, compound

Product 1

HCID 54560141HCID 54560141, compoundYield 17%

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

Prepared analogously to Example 1 from 4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 2-[4-[3-(dimethylamino)propyl]-piperidin-l-yl]ethanamine in a yield of 17% of theory. Colourless crystals, m.p. >300° C. (t-butylmethyl ether).

Sources & evidence

ORD record
ord-d824994e9a004847b5899bf609f977dc
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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