Acetonitrile → HCID 53925832, compound

HRID 2351444Notes

Reaction equation

HRID 2351444 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[CH2:20]([N:22]([CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][N:27]1[CH2:32][C:33]([CH3:36])([CH3:35])[NH2:34])[CH2:23][CH3:24])[CH3:21].C(#N)C>C(OCC)(=O)C>[CH2:20]([N:22]([CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][N:27]1[CH2:32][C:33]([NH:34][C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3])([CH3:35])[CH3:36])[CH2:23][CH3:24])[CH3:21]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 1104396211-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 14210026HCID 14210026, compound

Product 1

HCID 53925832HCID 53925832, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared analogously to Example 2 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-[(diethylamino)methyl]-piperidin-l-yl]-1,1-dimethyl-ethanamine in a yield of 62% of theory. Colourless crystals, m.p. 160°-162° C. (acetonitrile and ethyl acetate).

Sources & evidence

ORD record
ord-f301b755c7da491fa184b99b0263c528
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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