Methyl iodide → HCID 14770296, compound

HRID 2351459Notes

Reaction equation

HRID 2351459 reaction equation
[CH3:1][O:2][CH2:3][CH:4]1[C:7](=[O:8])[O:6][CH:5]1[CH2:9][CH2:10][CH2:11][CH2:12][CH:13]([CH3:18])[CH2:14][CH:15]([OH:17])[CH3:16].[CH3:19]I>CCOC(C)=O.[Ag]=O>[CH3:1][O:2][CH2:3][CH:4]1[C:7](=[O:8])[O:6][CH:5]1[CH2:9][CH2:10][CH2:11][CH2:12][CH:13]([CH3:18])[CH2:14][CH:15]([O:17][CH3:19])[CH3:16]

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 14770295HCID 14770295, compound

Product 1

HCID 14770296HCID 14770296, compound

Reagents, catalysts & solvents 2

HCID 92152Silver(II) oxideCatalystHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
60 °C

Procedure

10 mg of 8-(3-methoxymethyl-4-oxo-2-oxetanyl)-4-methyl-2-octanol in 1 ml of EtOAc was added a small amount of activated silver oxide and 0.5 ml of methyl iodide. The mixture was heated for 5.5 hours at 60° C. The solution was filtered and the filtrate was concentrated to dryness. The product was purified by flash chromatography to yield 8-(3-methoxymethyl-4-oxo-2-oxetanyl)-4-methyl-2-methoxyoctane. ##STR13##

Workup

  1. filtrationThe solution was filtered
  2. concentrationthe filtrate was concentrated to dryness
  3. customThe product was purified by flash chromatography

Sources & evidence

ORD record
ord-0796321c56c248e9b8fd05bdad600331
Source dataset
uspto-grants-1989_10
Patent number
US04873260

Reaction notes

Loading…