Hydrochloric Acid → HCID 15613923, compound

HRID 2351500Notes

Reaction equation

HRID 2351500 reaction equation
Cl[CH:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2([CH3:29])[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][C:21]([CH3:28])=[CH:22][C:23]=3[CH3:27])[O:18]2)=[CH:11][CH:10]=1)[C:3](OCC)=[O:4].[NH2:30][C:31](N)=[S:32].S1(CCCC1)(=O)=[O:35].Cl>COCCO>[CH3:29][C:17]1([CH2:16][O:15][C:12]2[CH:11]=[CH:10][C:9]([CH2:8][CH:2]3[S:32][C:31](=[O:35])[NH:30][C:3]3=[O:4])=[CH:14][CH:13]=2)[CH2:26][CH2:25][C:24]2[C:19](=[CH:20][C:21]([CH3:28])=[CH:22][C:23]=2[CH3:27])[O:18]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2723790ThioureaHCID 15671141HCID 15671141, compound

Product 1

HCID 15613923HCID 15613923, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

Following a procedure similar to that described in Example 1, but using 1.52 g of ethyl 2-chloro-3-[4-(2,5,7-trimethylchroman-2-ylmethoxy)phenyl]propionate (prepared as described in Preparation 27), 0.83 g of thiourea, 5 ml of sulfolane, 15 ml of ethylene glycol monomethyl ether and 4 ml of 3N aqueous hydrochloric acid, 1.18 g of the title compound were obtained as a pale yellow powder, softening at 85°-108° C.

Sources & evidence

ORD record
ord-2cc5fe51246f45c5aafd174f4e299d0c
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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