Hydrochloric Acid → HCID 15671166, compound

HRID 2351501Notes

Reaction equation

HRID 2351501 reaction equation
Cl[CH:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2([CH3:30])[CH2:26][C:25](=[O:27])[C:24]3[C:19](=[CH:20][C:21]([CH3:29])=[CH:22][C:23]=3[CH3:28])[O:18]2)=[CH:11][CH:10]=1)[C:3](OCC)=[O:4].[NH2:31][C:32](N)=[S:33].S1(CCCC1)(=O)=[O:36].Cl>COCCO>[CH3:30][C:17]1([CH2:16][O:15][C:12]2[CH:11]=[CH:10][C:9]([CH2:8][CH:2]3[S:33][C:32](=[O:36])[NH:31][C:3]3=[O:4])=[CH:14][CH:13]=2)[CH2:26][C:25](=[O:27])[C:24]2[C:19](=[CH:20][C:21]([CH3:29])=[CH:22][C:23]=2[CH3:28])[O:18]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2723790ThioureaHCID 15671150HCID 15671150, compound

Product 1

HCID 15671166HCID 15671166, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

Following a procedure similar to that described in Example 1, but using 1.5 g of ethyl 2-chloro-3-[4-(2,5,7-trimethyl-4-oxochroman-2-ylmethoxy)phenyl]propionate (prepared as described in Preparation 29), 0.4 g of thiourea, 1.5 ml of sulfolane, 10 ml of ethylene glycol monomethyl ether and 5 ml of 2N aqueous hydrochloric acid, 1.13 g of the title compound were obtained as a pale yellow powder.

Sources & evidence

ORD record
ord-93fef53386804142a6a666aa31f86938
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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