Hydrochloric Acid → HCID 15613925, compound

HRID 2351502Notes

Reaction equation

HRID 2351502 reaction equation
Cl[CH:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2([CH3:31])[CH2:26][CH2:25][C:24]3[C:19](=[C:20]([CH3:30])[C:21]([CH3:29])=[C:22]([CH3:28])[C:23]=3[CH3:27])[O:18]2)=[CH:11][CH:10]=1)[C:3](OCC)=[O:4].[NH2:32][C:33](N)=[S:34].S1(CCCC1)(=O)=[O:37].Cl>COCCO>[CH3:31][C:17]1([CH2:16][O:15][C:12]2[CH:11]=[CH:10][C:9]([CH2:8][CH:2]3[S:34][C:33](=[O:37])[NH:32][C:3]3=[O:4])=[CH:14][CH:13]=2)[CH2:26][CH2:25][C:24]2[C:19](=[C:20]([CH3:30])[C:21]([CH3:29])=[C:22]([CH3:28])[C:23]=2[CH3:27])[O:18]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2723790ThioureaHCID 15671142HCID 15671142, compound

Product 1

HCID 15613925HCID 15613925, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

Following a procedure similar to that described in Example 1, but using 361 mg of ethyl 2-chloro-3-[4-(2,5,6,7,8-pentamethylchroman-2-ylmethoxy)phenyl]propionate (prepared as described in Preparation 33), 309 mg of thiourea, 3 ml of sulfolane, 10 ml of ethylene glycol monomethyl ether and 5 ml of 3N aqueous hydrochloric acid, 290 mg of the title compound were obtained as a white powder, softening at 62°-64° C.

Sources & evidence

ORD record
ord-2e42f93405c64ff5b61eb539ad3c83fc
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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