Hydrochloric Acid → HCID 15613929, compound

HRID 2351510Notes

Reaction equation

HRID 2351510 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:32]=[CH:31][C:12]([O:13][CH2:14][C:15]3([CH3:30])[CH2:24][CH2:23][C:22]4[C:17](=[CH:18][CH:19]=[C:20]([C:25]([O:27]CC)=[O:26])[CH:21]=4)[O:16]3)=[CH:11][CH:10]=2)[S:3]1.Cl>C(O)(=O)C>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:32]=[CH:31][C:12]([O:13][CH2:14][C:15]3([CH3:30])[CH2:24][CH2:23][C:22]4[C:17](=[CH:18][CH:19]=[C:20]([C:25]([OH:27])=[O:26])[CH:21]=4)[O:16]3)=[CH:11][CH:10]=2)[S:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15671171HCID 15671171, compound

Product 1

HCID 15613929HCID 15613929, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A procedure similar to that described in Example 15 was repeated, except that 1.1 g of ethyl 2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-2-methylchroman-6-carboxylate (prepared as described in Example 17), 10 ml of acetic acid and 5 ml of 3N aqueous hydrochloric acid were used, to afford 814 mg of the title compound as colorless crystals, melting at 223°-225° C.

Sources & evidence

ORD record
ord-e6f9f81528fb45c188cfd51508e167c3
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

Loading…