Hydrochloric Acid → HCID 15671141, compound

HRID 2351521Notes

Reaction equation

HRID 2351521 reaction equation
N[C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][C:8]2([CH3:20])[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([CH3:19])=[CH:13][C:14]=3[CH3:18])[O:9]2)=[CH:4][CH:3]=1.[ClH:23].N([O-])=O.[Na+].[C:28]([O:32][CH2:33][CH3:34])(=[O:31])[CH:29]=[CH2:30]>O.CC(C)=O>[Cl:23][CH:29]([CH2:30][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][C:8]2([CH3:20])[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([CH3:19])=[CH:13][C:14]=3[CH3:18])[O:9]2)=[CH:4][CH:3]=1)[C:28]([O:32][CH2:33][CH3:34])=[O:31]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 15671137HCID 15671137, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 15671141HCID 15671141, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

A procedure similar to that described in Preparation 5 was repeated, except that 2.0 g of 2-(4-aminophenoxymethyl)-2,5,7-trimethylchroman (prepared as described in Preparation 26), 2 ml of concentrated aqueous hydrochloric acid, 560 mg of sodium nitrite, 15 ml of acetone, 3.5 ml of ethyl acrylate, 90 mg of cuprous oxide and 2 ml of water were reacted, to afford 1.53 g of the title compound as a pale yellow oil.

Workup

  1. customA procedure similar to that described in Preparation 5
  2. customwere reacted

Sources & evidence

ORD record
ord-4444a77614fb466ca143a812e280dd59
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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