Hydrochloric Acid → HCID 15671142, compound

HRID 2351524Notes

Reaction equation

HRID 2351524 reaction equation
N[C:2]1[CH:24]=[CH:23][C:5]([O:6][CH2:7][C:8]2([CH3:22])[CH2:17][CH2:16][C:15]3[C:10](=[C:11]([CH3:21])[C:12]([CH3:20])=[C:13]([CH3:19])[C:14]=3[CH3:18])[O:9]2)=[CH:4][CH:3]=1.[ClH:25].N([O-])=O.[Na+].[C:30]([O:34][CH2:35][CH3:36])(=[O:33])[CH:31]=[CH2:32]>O.CC(C)=O>[Cl:25][CH:31]([CH2:32][C:2]1[CH:24]=[CH:23][C:5]([O:6][CH2:7][C:8]2([CH3:22])[CH2:17][CH2:16][C:15]3[C:10](=[C:11]([CH3:21])[C:12]([CH3:20])=[C:13]([CH3:19])[C:14]=3[CH3:18])[O:9]2)=[CH:4][CH:3]=1)[C:30]([O:34][CH2:35][CH3:36])=[O:33]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 15671138HCID 15671138, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 15671142HCID 15671142, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

A procedure similar to that described in Preparation 5 was repeated, except that 734 mg of 2-(4-aminophenoxymethyl)-2,5,6,7,8-pentamethylchroman (prepared as described in Preparation 32), 1 ml of concentrated aqueous hydrochloric acid, 190 mg of sodium nitrite, 1.2 ml of ethyl acrylate, 70 mg of cuprous oxide, 10 ml of acetone and 2 ml of water were reacted, to afford 390 mg of the title compound as a pale yellow oil.

Workup

  1. customA procedure similar to that described in Preparation 5
  2. customwere reacted

Sources & evidence

ORD record
ord-545ea7f8054a4f418c0b2190dedf0feb
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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