Hydrochloric Acid → HCID 19913992, compound

HRID 2351556Notes

Reaction equation

HRID 2351556 reaction equation
[OH:1][CH:2]([CH2:32][OH:33])[CH2:3][O:4][C:5]1[N:6]=[N:7][C:8]([NH:11][NH:12][C:13](C2C=CC=CC=2)([C:20]2C=CC=CC=2)[C:14]2C=CC=CC=2)=[CH:9][CH:10]=1.[ClH:34]>O1CCCC1>[ClH:34].[OH:1][CH:2]([CH2:32][OH:33])[CH2:3][O:4][C:5]1[N:6]=[N:7][C:8]([NH:11][N:12]=[C:13]([CH3:14])[CH3:20])=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15020501HCID 15020501, compound

Product 1

HCID 19913992HCID 19913992, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (RS)-3-(2,3-dihydroxypropoxy)-6-(2-triphenylmethylhydrazino)pyridazine (3.2 g) in tetrahydrofuran (80 ml), conc. hydrochloric acid (2 ml) was added. After stirring at room temperature for 15 minutes the solution was concentrated under vacuum to small volume and diluted with acetone (50 ml). After stirring at room temperature for 30 minutes and then at 0° C. for 1 hour the precipitate was collected to yield 1.4 g of the title compound, identical to that obtained in Example 14.

Workup

  1. concentrationwas concentrated under vacuum to small volume
  2. additiondiluted with acetone (50 ml)
  3. stirringAfter stirring at room temperature for 30 minutes
  4. customat 0° C. for 1 hour the precipitate was collected

Sources & evidence

ORD record
ord-7cddbc6132884dd7b621459646a85db6
Source dataset
uspto-grants-1989_10
Patent number
US04873328

Reaction notes

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