HRID23518

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：Cc1ccc(S(=O)(=O)Sc2cc(C)c(CO)cc2C(C)(C)C)cc1

HCID10499026

未命名化合物

结构：CC(=O)Nc1nc(CCC2(C(C)C)CC(O)=CC(=O)O2)cs1

HCID54713486

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1nc(CCC2(C(C)C)CC(O)=C(Sc3cc(C)c(CO)cc3C(C)(C)C)C(=O)O2)cs1

HCID54677070

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The title compound was prepared according to General Method 16a using N-{4-[2-(4-hydroxy-2-isopropyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-thiazol-2-yl}-acetamide (Example E-13; 0.49 g, 1.5 mmol), toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl)ester (Example BB-2; 0.66 g, 1.8 mmol), potassium carbonate (0.83 g, 6.0 mmol), and DMF (5 mL). The product was chromatographed on silica gel, eluting with 5% MeOH in CH2Cl2, to give the title compound, mp 128-130° C.

WORKUP

后处理

customThe title compound was prepared
customThe product was chromatographed on silica gel
washeluting with 5% MeOH in CH2Cl2

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cd3184cc903b4e5fb85c2e10ee193264
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06852711B2
来源说明: uspto-grants-2005_02

反应 SMILES

[OH:1][C:2]1[CH2:3][C:4]([CH2:12][CH2:13][C:14]2[N:15]=[C:16]([NH:19][C:20](=[O:22])[CH3:21])[S:17][CH:18]=2)([CH:9]([CH3:11])[CH3:10])[O:5][C:6](=[O:8])[CH:7]=1.[C:23]([C:27]1[CH:32]=[C:31]([CH2:33][OH:34])[C:30]([CH3:35])=[CH:29][C:28]=1[S:36]S(C1C=CC(C)=CC=1)(=O)=O)([CH3:26])([CH3:25])[CH3:24].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:23]([C:27]1[CH:32]=[C:31]([CH2:33][OH:34])[C:30]([CH3:35])=[CH:29][C:28]=1[S:36][C:7]1[C:6](=[O:8])[O:5][C:4]([CH2:12][CH2:13][C:14]2[N:15]=[C:16]([NH:19][C:20](=[O:22])[CH3:21])[S:17][CH:18]=2)([CH:9]([CH3:11])[CH3:10])[CH2:3][C:2]=1[OH:1])([CH3:26])([CH3:25])[CH3:24]