Potassium Carbonate → HCID 14720281, compound

HRID 2351965Notes

Reaction equation

HRID 2351965 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.[CH:16]([S:19](Cl)(=[O:21])=[O:20])([CH3:18])[CH3:17].C(=O)([O-])[O-].[K+].[K+]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[S:19]([CH:16]([CH3:18])[CH3:17])(=[O:21])=[O:20])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 824082-Propanesulfonyl chlorideHCID 28045454-chloro-N-(pyridin-3-ylmethyl)aniline

Product 1

HCID 14720281HCID 14720281, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A 3.3 g. portion of 3-(4-chlorophenylaminomethyl)pyridine was dissolved in chloroform and reacted with 2.4 g. of isopropanesulfonyl chloride in the presence of 2.3 g. of potassium carbonate for several days at ambient temperature. The reaction mixture was worked up as described in Example 4, and the oily product was dissolved in chloroform and purified over silica gel, eluting with chloroform, to obtain 0.6 g. of the desired product, the elemental analysis which was as follows.

Workup

  1. customreacted with 2.4 g
  2. custompurified over silica gel
  3. washeluting with chloroform
  4. customto obtain 0.6 g

Sources & evidence

ORD record
ord-e1f8423e11bb4b69b7fdfca431db6319
Source dataset
uspto-grants-1989_10
Patent number
US04874775

Reaction notes

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