Sulfuric Acid → 4-Methoxybenzenesulfonyl chloride

Temperature

45 °C

With stirring, 51.5 g (0.525 m) of 100 percent sulfuric acid was added to a mixture of 54.0 g (0.5 m) of anisole and 46.0 ml (0.5 m) of phosphorus oxychloride allowing the temperature to rise to approximately 45° C. during the addition. While attempting to maintain approximately 45° C. the temperature slowly rose to approximately 53° C. after about two hours. After stirring overnight at ambient temperature, 6.0 g of sodium chloride was added and the resulting mixture was heated to and maintained at approximately 90° for about four hours. The reaction mixture was cooled and poured onto a mixture of 500.0 g ice, 250.0 ml of water and 30.0 g of sodium chloride. The solid which formed was collected by filtration, washed with cold water and dried to obtain 96.5 g of 4-methoxybenzenesulfonyl chloride a gray-white solid. The nuclear magnetic resonance spectrum was in accord with the desired product.

1. additionto rise to approximately 45° C. during the addition
2. stirringAfter stirring overnight at ambient temperature
3. temperaturethe resulting mixture was heated to and
4. temperaturemaintained at approximately 90° for about four hours
5. temperatureThe reaction mixture was cooled
6. customThe solid which formed
7. filtrationwas collected by filtration
8. washwashed with cold water
9. customdried

ORD record

ord-6fb3baa079434d5f8aae2e45b24d9f53

Source dataset

uspto-grants-1989_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04874894