5-Bromopyrimidine → HCID 19843738, compound

HRID 2352129Notes

Reaction equation

HRID 2352129 reaction equation
[CH:1]1([CH:4]=[O:5])[CH2:3][CH2:2]1.Br[C:7]1[CH:8]=[N:9][CH:10]=[N:11][CH:12]=1.C([Li])CCC>>[CH:1]1([CH:4]([C:7]2[CH:8]=[N:9][CH:10]=[N:11][CH:12]=2)[OH:5])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 783445-BromopyrimidineHCID 123114CyclopropanecarboxaldehydeHCID 178418339Butyllithium

Product 1

HCID 19843738HCID 19843738, compound

Procedure

Using the general method of Example 1, cyclopropanecarboxaldehyde (19 g, 0.27 mol) was reacted with 5-bromopyrimidine (43.2 g, 0.27 mol) and n-butyl lithium (108.6 ml of 2.5M, 0.27 mol) to give the product as a pale yellow oil.

Sources & evidence

ORD record
ord-64ef6b42574b4263bdea3e29d721fd37
Source dataset
uspto-grants-1989_10
Patent number
US04875922

Reaction notes

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