1-(2-Pyridyl)piperazine → HCID 86743469, compound

HRID 2352155Notes

Reaction equation

HRID 2352155 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[N:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>CO>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[N:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 944591-(2-Pyridyl)piperazineHCID 444266Maleic Acid

Product 1

HCID 86743469HCID 86743469, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of 465 mg. (0.004 mole) of maleic acid in 2 ml. of methanol was added to 327 mg. (0.002 mole) of 1-(2-pyridyl)-piperazine [K. L. Howard, H. W. Stewart, E. A. Conroy, ad J. J. Dentor, J. Org. Chem., 18, 1484 (1953)] in 1 ml. of methanol. The white solids which separated were recrystallized from methanol to yield 1-(2-pyridyl)-piperazine dimaleate, m.p. 140°-141° C.

Workup

  1. customThe white solids which separated
  2. customwere recrystallized from methanol

Sources & evidence

ORD record
ord-f8192e40d1c24052b30a461ac500fc9a
Source dataset
uspto-grants-1989_10
Patent number
US04876256

Reaction notes

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