2-Propanone, 1-nitro- → HCID 14230411, compound

HRID 2352157Notes

Reaction equation

HRID 2352157 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH:12]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:17]/[C:18](/[CH3:37])=[CH:19]\[C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH2:35][CH2:34][C:33](=[O:36])[NH:32][N:31]=2)=[CH:26][CH:25]=1)=[O:21].[N+:38]([CH2:41][C:42](=O)[CH3:43])([O-:40])=[O:39]>C(O)(C)C>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:12]2[C:41]([N+:38]([O-:40])=[O:39])=[C:42]([CH3:43])[NH:17][C:18]([CH3:37])=[C:19]2[C:20]([O:22][CH2:23][C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH2:35][CH2:34][C:33](=[O:36])[NH:32][N:31]=3)=[CH:28][CH:29]=2)=[O:21])[CH:14]=[CH:15][CH:16]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 662962-Propanone, 1-nitro-HCID 743423-BenzyloxybenzaldehydeHCID 70049071HCID 70049071, compound

Product 1

HCID 14230411HCID 14230411, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

10 mmol of 3-benzyloxybenzaldehyde and 10 mmol of 4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)benzyl 3-aminocrotonate are heated at 60° C. for 8 hours in 30 ml of i-propanol, a total of 20 mmol of nitroacetone being added in portions. The product crystallizes after addition of a little petroleum ether and trituration. It is recrystallized from a little i-propanol.

Workup

  1. customThe product crystallizes
  2. additionafter addition of a little petroleum ether and trituration
  3. customIt is recrystallized from a little i-propanol

Sources & evidence

ORD record
ord-1b1d20251cc347d8977b741e785c73b9
Source dataset
uspto-grants-1989_10
Patent number
US04876254

Reaction notes

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