反应详情

A 2.73 g portion of dry 4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenol was dissolved in 50 ml of dry dimethylformamide. A 528 mg portion of sodium hydride (50% in oil) was added, the reaction was sealed and stirred for 45 minutes. A solution of 1.33 g of allyl bromide in 10 ml of dimethylformamide was added, the sealed mixture was stirred overnight and then evaporated at 80° C. The residue was partitioned between water and chloroform. The organic phase was separated, dried and filtered. The filtrate was evaporated and the residue crystallized from chloroform-hexane, giving 1.7 g of the desired product as yellow crystals, mp 105°-108° C.

1. customthe reaction was sealed
2. stirringthe sealed mixture was stirred overnight
3. customevaporated at 80° C
4. customThe residue was partitioned between water and chloroform
5. customThe organic phase was separated
6. customdried
7. filtrationfiltered
8. customThe filtrate was evaporated
9. customthe residue crystallized from chloroform-hexane