Chlorotrifluoroethylene → 2-Chloro-N,N-diethyl-1,1,2-trifluoroethan-1-amine

HRID 2352351Notes

Reaction equation

HRID 2352351 reaction equation
[Cl:1][C:2]([F:6])=[C:3]([F:5])[F:4].[CH2:7]([NH:9][CH2:10][CH3:11])[CH3:8]>>[Cl:1][CH:2]([F:6])[C:3]([N:9]([CH2:10][CH3:11])[CH2:7][CH3:8])([F:5])[F:4]

Participants

3

Reactant 2

HCID 6594ChlorotrifluoroethyleneHCID 8021Diethylamine

Product 1

HCID 1361842-Chloro-N,N-diethyl-1,1,2-trifluoroethan-1-amineYield 56%

Procedure

Chlorotrifluoroethylene (454 g; 3.91 mole) is bubbled into diethylamine (350 g; 4.8 mole) over about 6 hours while the temperature is maintained at 30°-45° C. by use of an ice bath. The mixture is stirred overnight at room temperature and then distilled in vacuo to give 415 g (2.2M) of N-(2-chloro-1,1,2-trifluoroethyl)-diethylamine.

Workup

  1. temperatureis maintained at 30°-45° C. by use of an ice bath
  2. distillationdistilled in vacuo

Sources & evidence

ORD record
ord-d1868955c72840849d91a35b08cb579b
Source dataset
uspto-grants-1989_10
Patent number
US04876352

Reaction notes

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