4-Methylmorpholine → HCID 14819159, compound

HRID 2352396Notes

Reaction equation

HRID 2352396 reaction equation
Cl.[O:2]=[C:3]1[CH:7]([NH:8][C@H:9]([C:11]([OH:13])=O)[CH3:10])[CH2:6][CH2:5][O:4]1.CN1CCOCC1.[O:21]=[C:22]1[CH:26]([NH:27][C@H:28]([C:30](O)=O)C)[CH2:25][CH:24]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]CC)[O:23]1>>[CH2:24]([O:23][C:22](=[O:21])[C@@H:26]1[CH2:25][CH2:30][CH2:28][N:27]1[C:11](=[O:13])[C@H:9]([CH3:10])[NH:8][CH:7]1[CH2:6][CH2:5][O:4][C:3]1=[O:2])[C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

Participants

4

Reactant 3

HCID 79724-MethylmorpholineHCID 14819133HCID 14819133, compoundHCID 14819287HCID 14819287, compound

Product 1

HCID 14819159HCID 14819159, compound

Procedure

Conducting a reaction and treatments in the same manner as in Step (3) of Example 1 except that N-(2-oxo-3-tetrahydrofuranyl)-L-alanine hydrochloride was used in a form neutralized with N-methylmorpholine in place of Isomer BCD of N-(2-oxo-5-octyl-3-tetrahydrofuranyl)-L-alanine, was obtained as a colorless syrupy substance N-(2-oxo-3-tetrahydrofuranyl)-L-alanyl-L-proline benzyl ester [in the formula (I), R1 =R2 =H, R3 =CH3, R4 and R5 =--(CH2)3 --, R6 =-CH2Ph (Compound 13)].

Sources & evidence

ORD record
ord-746122d82b1e4960b038b057c5e729f2
Source dataset
uspto-grants-1989_10
Patent number
US04876359

Reaction notes

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