反应详情

To a mixture of 4-(2-pyridyloxy)phenol (0.75 g), anhydrous potassium carbonate (0.67 g), potassium iodide (0.07 g), cupuric oxide (0.02 g) and 7 ml of dimethyl formamide, was added 2-(1-bromoethyl)-5-ethoxy-1,3,4-thiadiazole (0.95 g) under stirring, and further stirred at 80° C. for one hour. After cooling and pouring water, the resulting solution was extracted with ethyl acetate, washed with water and then dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under a reduced pressure and the residue was purified on column chromatography to obtain 0.84 g of the compound (No. 1) described in Table 1.

1. stirringfurther stirred at 80° C. for one hour
2. temperatureAfter cooling
3. extractionthe resulting solution was extracted with ethyl acetate
4. washwashed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationEthyl acetate was distilled off under a reduced pressure
7. customthe residue was purified on column chromatography