Dimethylformamide → HCID 178423907, compound

HRID 235294Notes

Reaction equation

HRID 235294 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:16])[C:5](=NO)[C:6](=[O:13])[NH:7]2.CN(C=[O:21])C>Cl.[Pd]>[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[C:3]=1[C:4]([OH:16])=[C:5]([OH:21])[C:6]([OH:13])=[N:7]2

Participants

5

Reactant 2

HCID 6228DimethylformamideHCID 178423634HCID 178423634, compound

Product 1

HCID 178423907HCID 178423907, compoundYield 50%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 313Hydrochloric AcidSolvent

Procedure

The procedure of Baker and Almaula, J. Org. Chem. 27:4672-74 (1962), was adapted. A mixture of 5,7-dimethylquinoline-2,3,4-trione-3-oxime (45 mg, 0.21 mmol) and 30% Pd/C (10 mg) in DMF (2 mL) and 4N HCl (2 mL) was hydrogenated at 50 psi for 12 h. A crystalline colorless solid was observed in the reaction mixture. The mixture was filtered and the solid was stirred with acetone/methanol (1:1) and filtered to remove the black catalyst. The acetone/methanol solution was added into the 1N HCl solution (10 mL) to give white crystals. It was filtered and washed with water (1×1 mL), and dried to leave 21 mg of the title compound (50%), which is pure by NMR. mp 280°-2° C. IR (KBr, cm-1): 3452, 3178, 3108, 1663, 1621, 1585. 1H NMR (DMSO-d6): δ 2.248 (s, 3H); 2.638 (s, 3H); 6.704 (s, 1H); 6.876 (s, 1H); 8.595 (s, 1H); 9.542 (s, 1H); 11.424 (s, 1H). HRMS: calcd for C11H11NO3 m/z: 205.0738; found: 205.0729. Purity:>99% by HPLC (tautomers 71.5% and 28.4%).

Workup

  1. filtrationThe mixture was filtered
  2. filtrationfiltered
  3. customto remove the black catalyst
  4. additionThe acetone/methanol solution was added into the 1N HCl solution (10 mL)
  5. customto give white crystals
  6. filtrationIt was filtered
  7. washwashed with water (1×1 mL)
  8. customdried

Sources & evidence

ORD record
ord-bfbb41e4f09e4c0a91667632352ea854
Source dataset
uspto-grants-1997_01
Patent number
US05597922

Reaction notes

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