Carbon Dioxide → HCID 131728238, compound

HRID 2353000Notes

Reaction equation

HRID 2353000 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[S:14][C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:7]([CH2:15][C:16]34[CH2:23][CH2:22][N:19]([CH2:20][CH2:21]3)[CH2:18][CH2:17]4)[C:5]=2[CH:6]=1.[CH2:24]([OH:100])[C@H:25]1[O:30][C@@H:29]2[O:31][C@H:32]3[C@H:37]([OH:38])[C@@H:36]([OH:39])[C@@H:35]([O:40][C@H:41]4[C@H:46]([OH:47])[C@@H:45]([OH:48])[C@@H:44]([O:49][C@H:50]5[C@H:55]([OH:56])[C@@H:54]([OH:57])[C@@H:53]([O:58][C@H:59]6[C@H:64]([OH:65])[C@@H:63]([OH:66])[C@@H:62]([O:67][C@H:68]7[C@H:73]([OH:74])[C@@H:72]([OH:75])[C@@H:71]([O:76][C@H:77]8[C@H:83]([OH:84])[C@@H:82]([OH:85])[C@@H:80]([O:81][C@H:26]1[C@H:27]([OH:99])[C@H:28]2[OH:98])[O:79][C@@H:78]8[CH2:86][OH:87])[O:70][C@@H:69]7[CH2:88][OH:89])[O:61][C@@H:60]6[CH2:90][OH:91])[O:52][C@@H:51]5[CH2:92][OH:93])[O:43][C@@H:42]4[CH2:94][OH:95])[O:34][C@@H:33]3[CH2:96][OH:97].C(=O)=O>O>[CH:10]1[CH:11]=[CH:12][C:13]2[S:14][C:4]3[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=3[N:7]([CH2:15][C:16]34[CH2:17][CH2:18][N:19]([CH2:20][CH2:21]3)[CH2:22][CH2:23]4)[C:8]=2[CH:9]=1.[CH2:90]([OH:91])[C@H:60]1[O:61][C@@H:62]2[O:67][C@H:68]3[C@H:73]([OH:74])[C@@H:72]([OH:75])[C@@H:71]([O:76][C@H:77]4[C@H:83]([OH:84])[C@@H:82]([OH:85])[C@@H:80]([O:81][C@H:26]5[C@H:27]([OH:99])[C@@H:28]([OH:98])[C@@H:29]([O:31][C@H:32]6[C@H:37]([OH:38])[C@@H:36]([OH:39])[C@@H:35]([O:40][C@H:41]7[C@H:46]([OH:47])[C@@H:45]([OH:48])[C@@H:44]([O:49][C@H:50]8[C@H:55]([OH:56])[C@@H:54]([OH:57])[C@@H:53]([O:58][C@H:59]1[C@H:64]([OH:65])[C@H:63]2[OH:66])[O:52][C@@H:51]8[CH2:92][OH:93])[O:43][C@@H:42]7[CH2:94][OH:95])[O:34][C@@H:33]6[CH2:96][OH:97])[O:30][C@@H:25]5[CH2:24][OH:100])[O:79][C@@H:78]4[CH2:86][OH:87])[O:70][C@@H:69]3[CH2:88][OH:89]

Participants

5

Reactant 3

HCID 280Carbon DioxideHCID 444041beta-CyclodextrinHCID 15662541HCID 15662541, compound

Product 1

HCID 131728238HCID 131728238, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.5 grams of mequitazine in racemic or L- or D-form, 20.11 grams of β-cyclodextrin, and 5.11 grams of water are mixed and introduced into a 500 ml reactor. Carbon dioxide is then introduced into the reactor under a pressure of 15 MPa and at a temperature of 75° C. The unit is maintained under these operating conditions for 2 hours. The powder thus collected after releasing the medium is placed in a drying oven at 60° C. overnight.

Workup

  1. additionintroduced into a 500 ml reactor
  2. temperatureThe unit is maintained under these operating conditions for 2 hours
  3. customThe powder thus collected

Sources & evidence

ORD record
ord-9f2eafb09eb74f7b9aff34a4d60680c7
Source dataset
uspto-grants-2010_07
Patent number
US07749982B2

Reaction notes

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