1-(4-Nitrophenyl)piperazine → HCID 57419550, compound

HRID 2353228Notes

Reaction equation

HRID 2353228 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:16][O:17][C:18](=[O:23])[CH2:19][CH2:20][CH2:21]Br>>[CH3:16][O:17][C:18](=[O:23])[CH2:19][CH2:20][CH2:21][N:13]1[CH2:14][CH2:15][N:10]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 804471-(4-Nitrophenyl)piperazineHCID 107604Methyl 4-bromobutyrate

Product 1

HCID 57419550HCID 57419550, compoundYield 52.6%

Procedure

The title compound (1.56 g, 52.6%) was synthesized from 1-(4-nitro-phenyl)-piperazine (2 g, 9.66 mmol) and 4-bromo-butyric acid methyl ester (1.75 g, 9.83 mmol) by the procedure described in step 1 of Example 1 MS (ESI) m/z 264 (M+H); 1H NMR (400 MHz, CDCl3) δ 1.86 (m, 2H), 2.39 (m, 4H), 2.58 (t, J=5.2 Hz, 4H), 3.41 (t, J=5.2, 4H), 3.68 (s, 3H), 6.81 (m, 2H), 8.12 (m, 2H).

Sources & evidence

ORD record
ord-0292944d93974d379c83d7169ac43b01
Source dataset
uspto-grants-2010_07
Patent number
US07750012B2

Reaction notes

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