Hydrochloric Acid → HCID 44818805, compound

HRID 2353245Notes

Reaction equation

HRID 2353245 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]3[CH:26]=[CH:25][C:24]([I:27])=[CH:23][CH:22]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:28]>O1CCOCC1>[ClH:28].[I:27][C:24]1[CH:25]=[CH:26][C:21]([O:20][C:17]2[CH:16]=[CH:15][C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:19][CH:18]=2)=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 44818989HCID 44818989, compound

Product 1

HCID 44818805HCID 44818805, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound (1.3 g, 95%) was prepared from the compound from step 1 (1.35 g, 3.8 mmol) and 4N HCl in dioxane by the procedure described in step 2 of Example 4: MS (ESI) m/z 381 (M+H); 1H NMR (400 MHz, DMSO-d6) δ 3.22 (br, 4H), 3.32 (t, J=5.6 Hz, 4H), 6.74 (d, J=8.8 Hz, 2H), 6.98-7.03 (m, 4H), 7.65 (d, J=8.8 Hz, 2H), 9.05 (br, 1H).

Sources & evidence

ORD record
ord-acfedc3608c24d828cedd6d76b28d3c4
Source dataset
uspto-grants-2010_07
Patent number
US07750012B2

Reaction notes

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