m-Chloroperbenzoic acid → HCID 178425814, compound

HRID 2353393Notes

Reaction equation

HRID 2353393 reaction equation
[CH:1]1([NH:4][C:5](=[O:29])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([C:13]3[CH:21]=[C:20]4[C:16]([C:17]([C:22]5[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=5)=[N:18][NH:19]4)=[CH:15][C:14]=3[F:28])[CH:7]=2)[CH2:3][CH2:2]1.C1C=C(Cl)C=C(C(OO)=[O:38])C=1>C(Cl)(Cl)Cl>[CH:1]1([NH:4][C:5](=[O:29])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([C:13]3[CH:21]=[C:20]4[C:16]([C:17]([C:22]5[CH:27]=[CH:26][N+:25]([O-:38])=[CH:24][CH:23]=5)=[N:18][NH:19]4)=[CH:15][C:14]=3[F:28])[CH:7]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 11338162HCID 11338162, compound

Product 1

HCID 178425814HCID 178425814, compoundYield 56.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of N-cyclopropyl-3-[5-fluoro-3-(4-pyridinyl)-1H-indazol-6-yl]-4-methylbenzamide (Example 1, 9.3 mg) and m-CPBA (20 mg) in chloroform (2 ml) was stirred under nitrogen at 60° C. for 1 h. The mixture was applied to an Isolute amino cartridge (1 g) and eluted with chloroform/methanol (100:0 and 90:10 to give the title compound as a yellow solid (5.5 mg).

Workup

  1. washeluted with chloroform/methanol (100:0 and 90:10

Sources & evidence

ORD record
ord-a644c622369747858e6099355e2d447b
Source dataset
uspto-grants-2010_07
Patent number
US07750026B2

Reaction notes

Loading…