Triethylamine → 2-(Tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate

HRID 2353477Notes

Reaction equation

HRID 2353477 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][OH:9])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>O1CCCC1>[CH3:17][S:18]([O:9][CH2:8][CH2:7][CH:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 177509442-(Oxan-4-yl)ethan-1-ol

Product 1

HCID 222730832-(Tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product of Example 8A (2.9 mmol), triethylamine (1.2 mL, 8.7 mmol) and methanesulfonyl chloride (0.34 mL, 4.4 mmol) in 10 mL tetrahydrofuran (THF) were reacted and the product isolated as in Example 1C to give the title compound that was used directly in the next reaction.

Workup

  1. customthe product isolated as in Example 1C

Sources & evidence

ORD record
ord-5558016ad17a4b35ba003f0068e1fa24
Source dataset
uspto-grants-2010_07
Patent number
US07750039B2

Reaction notes

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