Triethylamine → 2,5-Pyrrolidinedione, 1-[2-[(methylsulfonyl)oxy]ethyl]-

HRID 2353482Notes

Reaction equation

HRID 2353482 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[CH2:7][CH2:6][C:5]1=[O:10].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C1COCC1>[CH3:18][S:19]([O:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[CH2:7][CH2:6][C:5]1=[O:10])(=[O:21])=[O:20]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 236334N-(2-Hydroxyethyl)succinimide

Product 1

HCID 100822242,5-Pyrrolidinedione, 1-[2-[(methylsulfonyl)oxy]ethyl]-

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The N-(2-hydroxyethyl)succinimide (Aldrich, 0.19 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Sources & evidence

ORD record
ord-377c69ae356f42ff83e7b22408d457a9
Source dataset
uspto-grants-2010_07
Patent number
US07750039B2

Reaction notes

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