Triethylamine → 2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

HRID 2353499Notes

Reaction equation

HRID 2353499 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:8][O:7][C:6]([CH3:10])([CH3:9])[O:5]1.C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C1COCC1>[CH3:18][S:19]([O:1][CH2:2][CH2:3][CH:4]1[CH2:8][O:7][C:6]([CH3:10])([CH3:9])[O:5]1)(=[O:21])=[O:20]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 42197542-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol

Product 1

HCID 131945362-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The 4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (Aldrich, 0.19 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Sources & evidence

ORD record
ord-0f4e44f084d64a6a95c19b9b701276bf
Source dataset
uspto-grants-2010_07
Patent number
US07750039B2

Reaction notes

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