Hydrochloric Acid → HCID 86093247, compound

HRID 2353609Notes

Reaction equation

HRID 2353609 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][F:18])=[CH:11][C:10]=1[O:19][CH3:20])(C)(C)C.[ClH:22]>C(O)(=O)C>[ClH:22].[F:18][CH2:17][CH2:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][NH2:7])=[C:10]([O:19][CH3:20])[CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86619060HCID 86619060, compound

Product 1

HCID 86093247HCID 86093247, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The above [4-(2-fluoro-ethoxy)-2-methoxy-benzyl]-carbamic acid tert-butyl ester (9.9 mg, 0.33 mmol) is treated with 37% aq. HCl (0.1 mL) and acetic acid (1 mL) for 1.5 h at rt. The solvents are removed by lyophilisation to give 4-(2-fluoro-ethoxy)-2-methoxy-benzylamine hydrochloride (7.8 mg) as a beige resin. LC-MS: tR=0.73 min, [M+1]+=200.04.

Workup

  1. customThe solvents are removed by lyophilisation

Sources & evidence

ORD record
ord-75a0225724634b0681ade52c20717b5f
Source dataset
uspto-grants-2010_07
Patent number
US07750040B2

Reaction notes

Loading…