Dipentafluorophenylcarbonate → HCID 58816578, compound

HRID 2354067Notes

Reaction equation

HRID 2354067 reaction equation
[CH2:1]([C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5]([CH3:10])[N:4]=1)[CH3:2].[F:11][C:12]1[C:17]([O:18][C:19](=O)[O:20]C2C(F)=C(F)C(F)=C(F)C=2F)=[C:16]([F:33])[C:15]([F:34])=[C:14]([F:35])[C:13]=1[F:36]>C1COCC1>[F:11][C:12]1[C:17]([O:18][C:19](=[O:20])[NH:9][C:7]2[CH:6]=[C:5]([CH3:10])[N:4]=[C:3]([CH2:1][CH3:2])[CH:8]=2)=[C:16]([F:33])[C:15]([F:34])=[C:14]([F:35])[C:13]=1[F:36]

Participants

4

Reactant 2

HCID 2734833DipentafluorophenylcarbonateHCID 55285766HCID 55285766, compound

Product 1

HCID 58816578HCID 58816578, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 2-ethyl-6-methyl-pyridin-4-ylamine (1.33 g, 9.8 mmol) in THF (25 mL) is slowly added to a solution of bis(pentafluorophenyl)carbonate (3.99 g, 10.1 mmol) in THF (10 mL). The mixture is stirred at r.t. for 48 h and the solution of title compound is used as stock solution for subsequent coupling reactions.

Sources & evidence

ORD record
ord-622c78cf3993419b999429b8e85d2f9e
Source dataset
uspto-grants-2010_07
Patent number
US07750161B2

Reaction notes

Loading…