Hydrochloric Acid → HCID 66919068, compound

HRID 2354234Notes

Reaction equation

HRID 2354234 reaction equation
[ClH:1].[CH:2]1([NH:5][C:6](=[O:31])[C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([N:14]3[C:23](=[O:24])[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([S:25][CH2:26][CH2:27][N:28]([CH3:30])[CH3:29])[CH:21]=4)[N:16]=[CH:15]3)[CH:8]=2)[CH2:4][CH2:3]1>O1CCOCC1>[ClH:1].[CH:2]1([NH:5][C:6](=[O:31])[C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([N:14]3[C:23](=[O:24])[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([S:25][CH2:26][CH2:27][N:28]([CH3:30])[CH3:29])[CH:21]=4)[N:16]=[CH:15]3)[CH:8]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66919015HCID 66919015, compound

Product 1

HCID 66919068HCID 66919068, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using an analogous procedure to that described in Example 45, 4N HCl in dioxane was reacted with N-cyclopropyl-3-[6-{[2-(dimethylamino)ethyl]thio}-4-oxoquinazolin-3 (4H)-yl]4-methylbenzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.58 (m, 2H), 0.70 (m, 2H), 2.15 (s, 3H), 2.70 (s, 6H), 2.85 (m, 1H), 3.14 (t, 2H), 3.45 (m, 2H), 7.53 (d, 1H), 7.78 (d, 1H), 7.85 (s, 1H), 7-91 (d, 1H), 7.95 (d, 1H), 8.12 (s, 1H), 8.31 (s, 1H), 8.50 (d, 1H), 10.65 (br s, 1H)

Sources & evidence

ORD record
ord-52c3e8fc59494296963fcd15a45aa683
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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