Methanesulfonic Acid → HCID 86610965, compound

HRID 2354237Notes

Reaction equation

HRID 2354237 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH:6]1([NH:9][C:10](=[O:38])[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([N:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:29][C@H:30]5[CH2:34][CH2:33][N:32]([CH:35]([CH3:37])[CH3:36])[CH2:31]5)[CH:25]=4)[N:20]=[CH:19]3)[CH:12]=2)[CH2:8][CH2:7]1>C(OCC)(=O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH:6]1([NH:9][C:10](=[O:38])[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([N:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:29][C@H:30]5[CH2:34][CH2:33][N:32]([CH:35]([CH3:36])[CH3:37])[CH2:31]5)[CH:25]=4)[N:20]=[CH:19]3)[CH:12]=2)[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 11374246HCID 11374246, compound

Product 1

HCID 86610965HCID 86610965, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using an analogous procedure to that described in Example 45, 1N methanesulfonic acid in ethyl acetate was reacted with N-cyclopropyl-3-[6-{[(3S)-1-isopropylpyrrolidin-3-yl]oxy}-4-oxoquinazolin-3(4H)-yl]-4-methylbenzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.56 (m, 2H), 0.70 (m, 2H), 1.30 (m, 6H), 2.14 (s, 3H), 2.26 (m, 1H), 2.36 (s, 3H), 2.85 (m, 1H), 3.27-4.00 (m, 6H), 5.38 (m, 1H), 7.54 (d, 1H), 7.58 (d, 1H), 7.63 (s, 1H), 7.80 (d, 1H), 7.84 (s, 1H), 7.91 (d, 1H), 8.23 (s, 1H), 8.45 (m, 1H), 9.95 (br d, 1H).

Sources & evidence

ORD record
ord-cae97fd9b35c47548bd14e7bcebf86f3
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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