Methanesulfonic Acid → HCID 86610971, compound

HRID 2354243Notes

Reaction equation

HRID 2354243 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH:6]1([NH:9][C:10](=[O:35])[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([N:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([CH2:29][CH2:30][CH2:31][N:32]([CH3:34])[CH3:33])[CH:25]=4)[N:20]=[CH:19]3)[CH:12]=2)[CH2:8][CH2:7]1>C(OCC)(=O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH:6]1([NH:9][C:10](=[O:35])[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([N:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([CH2:29][CH2:30][CH2:31][N:32]([CH3:33])[CH3:34])[CH:25]=4)[N:20]=[CH:19]3)[CH:12]=2)[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 66918943HCID 66918943, compound

Product 1

HCID 86610971HCID 86610971, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using an analogous procedure to that described in Example 45, two equivalents of 1N methanesulfonic acid in ethyl acetate was reacted with N-cyclopropyl-3-[6-[3-(dimethylamino)propyl]-4-oxoquinazolin-3(4H)-yl]-4-methylbenzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.70 (m, 2H), 1.91 (s, 2H), 2.15 (s, 3H), 2.40 (s, 6H), 2.80 (d, 6H), 2.82-2.90 (m, 3H), 3.10 (m, 2H), 7.54 (d, 1H), 7.76 (d, 1H), 7.83 (m, 2H), 7.92 (m, 1H), 8.10 (d, 1H), 8.31 (s, 1H), 8.46 (d, 1H), 9.35 (s, 1H).

Sources & evidence

ORD record
ord-97a6754b4348456c816122bfb25122c7
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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