Potassium Carbonate → 3-(4-Bromophenyl)propan-1-ol

To a solution of 3-(4-bromophenyl)propionic acid (1.0 g) in tetra hydrofuran (15 mL) was added borane tetra hydrofuran complex (1.0 mol/L tetra hydrofuran solution, 6.55 mL) under ice-cooling, and the mixture was stirred at room temperature for 2 hours. To the reaction mixture was added 20% aqueous potassium carbonate solution under ice-cooling, and the resulting mixture was extracted with ethylacetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give 3-(4-bromophenyl)propanol (0.93 g). The title compound was prepared in a similar manner to that described in Reference Example 55 using this material instead of 2-(4-bromo-phenyl)ethanol.

1. temperaturecooling
2. temperaturecooling
3. extractionthe resulting mixture was extracted with ethylacetate
4. washThe extract was washed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. customThe solvent was removed under reduced pressure

ORD record

ord-c421cc4fe4ea460f8e8ab435f6d671b9

Source dataset

uspto-grants-2010_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07750145B2