Water → HCID 59809683, compound

HRID 2354337Notes

Reaction equation

HRID 2354337 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:15][CH3:16])[CH2:9][N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:7]=1.[Cl:17][C:18]1[CH:19]=[C:20]([N:25]([CH3:30])[CH2:26][C:27]([OH:29])=O)[CH:21]=[CH:22][C:23]=1[Cl:24].C(N(CC)CC)C.O>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([N:15]([CH3:16])[C:27](=[O:29])[CH2:26][N:25]([C:20]2[CH:21]=[CH:22][C:23]([Cl:24])=[C:18]([Cl:17])[CH:19]=2)[CH3:30])[CH2:9][N:10]2[CH2:11][CH2:12][CH2:13][CH2:14]2)[CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 57418650N-(3,4-dichlorophenyl)-N-methylglycineHCID 57501273HCID 57501273, compound

Product 1

HCID 59809683HCID 59809683, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

[1-(3-Bromophenyl)-2-(1-pyrrolidinyl)ethyl]methylamine (0.65 g, 2.30 mmol) was added to a solution of N-(3,4-dichlorophenyl)-N-methylglycine (0.65 g, 2.30 mmol), (benzotriazol-1-yloxy) tris(dimethylamino)phosphonium-hexafluorophosphate (BOP) (1.52 g, 3.40 mmol) and triethylamine (TEA) (0.70 g, 6.90 mmol) in N,N-dimethyl-formamide (DMF) (10 mL). The reaction mixture was stirred at RT for 12 h. Water (10 mL) was then added an the crude compound precipitated, was filtered and crystallized from ether and hexane to give the title compound as an off-white solid (0.62 g, 54%). MS (ES) m/e 499[M+H]+.

Workup

  1. customprecipitated
  2. filtrationwas filtered
  3. customcrystallized from ether and hexane

Sources & evidence

ORD record
ord-5c9d7c6296294dbf986f25e633a0a0a4
Source dataset
uspto-grants-2010_07
Patent number
US07749998B2

Reaction notes

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