反应详情

To a solution of 2-amino-5-methyl-4-(methyloxy)phenol (1.54 g, 10 mmol) in THF (60 mL) was added carbodiimidazole (1.94 g, 12 mmol). The reaction mixture was stirred for 3 hours at room temperature, concentrated, diluted with EtOAc (100 mL), washed with 1N HCl, H2O, brine, and dried (Na2SO4). The solvent was removed via rotovap to give the title compound (1.76 g, 98%) as a white solid. MS (ES) m/e 180 [M+H]+.

1. concentrationconcentrated
2. additiondiluted with EtOAc (100 mL)
3. washwashed with 1N HCl, H2O, brine
4. dry with materialdried (Na2SO4)
5. customThe solvent was removed via rotovap