Lithium Hydroxide → HCID 68455358, compound

HRID 2354373Notes

Reaction equation

HRID 2354373 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([CH3:17])([C:12]([O:14]CC)=[O:13])[CH3:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[Li+:18].[OH-]>C1COCC1.O>[Li+:18].[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([CH3:17])([C:12]([O-:14])=[O:13])[CH3:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 59809613HCID 59809613, compound

Product 1

HCID 68455358HCID 68455358, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A 50-mL round bottom flask equipped with a magnetic stirring bar was charged with ethyl N-(3,4-dichlorophenyl)-2-methylalaninate (790 mg, 2.9 mmol) and dissolved in 3 mL of THF. A solution of LiOH (132 mg, 5.8 mmol) dissolved in 1.0 mL of H2O was added and the mixture was stirred at room temperature for 24 h. The solvent was removed under reduced pressure. A total of 846 mg (90%) of N-(3,4-dichlorophenyl)-2-methylalanine as a yellow solid was recovered as the lithium salt, after drying under vacuum for 24 h. MS (ES) m/z 248 [M+H]+

Workup

  1. customA 50-mL round bottom flask equipped with a magnetic stirring bar
  2. additionwas added
  3. customThe solvent was removed under reduced pressure
  4. customA total of 846 mg (90%) of N-(3,4-dichlorophenyl)-2-methylalanine as a yellow solid was recovered as the lithium salt
  5. customafter drying under vacuum for 24 h

Sources & evidence

ORD record
ord-0aa45c5880f4437b9e03f7339f68a4f8
Source dataset
uspto-grants-2010_07
Patent number
US07749998B2

Reaction notes

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