Dimethylformamide → 6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide

HRID 2354581Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2354581
[CH2:1]([NH:3][C:4]1[N:9]=[C:8]([C:10]2[CH:11]=[C:12]([C:17]([OH:19])=O)[C:13](=[O:16])[NH:14][N:15]=2)[CH:7]=[CH:6][N:5]=1)[CH3:2].CN(C=O)C.C(N(CC)CC)C.[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([NH2:39])=[C:35]([NH2:40])[CH:34]=1>O>[NH2:40][C:35]1[CH:34]=[C:33]([Cl:32])[CH:38]=[CH:37][C:36]=1[NH:39][C:17]([C:12]1[C:13](=[O:16])[NH:14][N:15]=[C:10]([C:8]2[CH:7]=[CH:6][N:5]=[C:4]([NH:3][CH2:1][CH3:2])[N:9]=2)[CH:11]=1)=[O:19]

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 72634-Chloro-1,2-diaminobenzeneHCID 8471TriethylamineHCID 684533256-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid

Produkt 1

HCID 866116046-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 110 mg of 6-(2-ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid, 2 ml of DMF and 0.17 ml of triethylamine is mixed with 192 mg of Hatu and stirred at room temperature for 30 minutes. Then 66 mg of 4-chlorophenylenediamine are added, and the mixture is stirred at room temperature overnight. 5 ml of water are added to the mixture, and the precipitate is briefly stirred and then filtered off with suction and dried.

Aufarbeitung

  1. stirringthe mixture is stirred at room temperature overnight
  2. stirringthe precipitate is briefly stirred
  3. filtrationfiltered off with suction
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e2c58e43cc4f4a05bfee3ae839289dc5
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07754713B2

Notizen zur Reaktion

Wird geladen…