12-Methyl-5-(4-methoxybenzyl)-3,4,5,12-tetraaza-tricyclo[6.3.1.02,6]dodeca-2(6),3-diene → HCID 178479866, compound

HRID 2354898Notes

Reaction equation

HRID 2354898 reaction equation
[CH3:1][N:2]1[CH:10]2[CH2:11][CH2:12][CH2:13][CH:3]1[C:4]1[N:5]=[N:6][N:7](CC3C=CC(OC)=CC=3)[C:8]=1[CH2:9]2>FC(F)(F)C(O)=O>[CH3:1][N:2]1[CH:10]2[CH2:11][CH2:12][CH2:13][CH:3]1[C:4]1[N:5]=[N:6][NH:7][C:8]=1[CH2:9]2

Participants

3

Reactant 1

HCID 5967949812-Methyl-5-(4-methoxybenzyl)-3,4,5,12-tetraaza-tricyclo[6.3.1.02,6]dodeca-2(6),3-diene

Product 1

HCID 178479866HCID 178479866, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

12-Methyl-5-(4-methoxybenzyl)-3,4,5,12-tetraaza-tricyclo[6.3.1.02,6]dodeca-2(6),3-diene (0.5 g, 1.7 mmol) in trifluoroacetic acid (TFA) (6 mL) was heated at 65° C. overnight. The solvent was removed and the residue was purified by prep HPLC to afford the product (200 mg, 1.1 mmol, 65% yield) as yellow oil.

Workup

  1. customThe solvent was removed
  2. customthe residue was purified by prep HPLC

Sources & evidence

ORD record
ord-cec563aa954a4038a0d82f1b0dc5bede
Source dataset
uspto-grants-2010_07
Patent number
US07754712B2

Reaction notes

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