Dichloromethane → HCID 86625823, compound

HRID 2355050Notes

Reaction equation

HRID 2355050 reaction equation
C([O:5][C:6](=[O:17])[NH:7][CH2:8][CH2:9][C:10](=[O:16])[NH:11][CH2:12][CH:13]([F:15])[F:14])(C)(C)C.ClCCl>Cl.O1CCOCC1>[F:14][CH:13]([F:15])[CH2:12][NH:11][C:10]([CH2:9][CH2:8][NH:7][C:6](=[O:5])[OH:17])=[O:16]

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 59383108HCID 59383108, compound

Product 1

HCID 86625823HCID 86625823, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

[2-(2,2-Difluoro-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (2.75 g, 10.9 mmol) was suspended in 4M hydrochloric acid in dioxane (30 ml) and stirred at RT for 18 h. Dichloromethane was added (50 ml) and the solid filtered off and dried in vacuo (2.02 g, 100%).

Workup

  1. filtrationthe solid filtered off
  2. customdried in vacuo (2.02 g, 100%)

Sources & evidence

ORD record
ord-150a3d916a3b4a4aa4e3256c6808b101
Source dataset
uspto-grants-2010_07
Patent number
US07754746B2

Reaction notes

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